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目的:探讨应用盐酸二甲双胍配合促排卵药治疗多囊卵巢综合征(PCOS)引起不孕的临床效果。方法:选择该院不孕症门诊就诊的患者,分成PCOS组102例,调月经周期同时服盐酸二甲双胍2～3个月后,促排卵治疗;非PCOS组490例,对月经不调和有内分泌疾病的患者调月经周期同时治疗内分泌疾病2～3个月后,促排卵治疗。观察治疗后的妊娠率、卵巢过度刺激综合征(OHSS)发生率、多胎妊娠和早期流产发生情况。结果:PCOS组的妊娠率、OHSS发生率明显高于非PCOS组,P<0.01;多胎发生情况也高于非PCOS组,P<0.01;早期流产的发生无明显差异,P>0.05。结论:盐酸二甲双胍配合促排卵治疗多囊卵巢综合征引起不孕的临床效果较好,能明显提高妊娠率,OHSS发生率在15%～16%,且程度较轻,结局良好。但是PCOS不孕患者促排卵时OHSS的发生和多胎妊娠很难完全避免。
Objective: To investigate the clinical effect of applying metformin hydrochloride combined with ovulation induction in the treatment of infertility caused by polycystic ovary syndrome (PCOS). Methods: A total of 102 outpatients with infertility clinics were divided into two groups: PCOS group (n = 102) and menstrual cycle with metformin hydrochloride (n = 2) for 2 to 3 months. Ovulation was induced in 490 cases of non-PCOS patients, Of patients transferred menstrual cycle at the same time treatment of endocrine disease 2 to 3 months after ovulation induction treatment. Observe the pregnancy rate after treatment, ovarian hyperstimulation syndrome (OHSS) incidence, multiple pregnancy and early abortion. Results: The pregnancy rate and OHSS incidence in PCOS group were significantly higher than those in non-PCOS group (P <0.01). The incidence of multiple births was also higher in non-PCOS group than in non-PCOS group (P <0.01). There was no significant difference in the incidence of early miscarriage (P> 0.05). Conclusion: Metformin Hydrochloride combined with ovulation induction treatment of polycystic ovary syndrome caused by infertility clinical effect is good, can significantly improve the pregnancy rate, OHSS incidence of 15% to 16%, and to a lesser extent, the outcome is good. However, PCOS infertility patients ovulation OHSS and multiple pregnancy is difficult to completely avoid.