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【目的】评价抗菌药物辅助治疗活动期中、重度慢性溃疡性结肠炎的疗效。【方法】对有关抗菌药物辅助治疗活动期中、重度慢性溃疡性结肠炎的前瞻性临床试验进行Meta分析。【结果】抗菌药物辅助治疗的有效率比安慰剂高 9%～2 8%,平均高 18%,效率差异有显著性 (P <0 0 0 0 1)。【结论】抗菌药物辅助治疗活动期中、重度慢性溃疡性结肠炎有临床应用价值。
【Objective】 To evaluate the efficacy of antimicrobial agents in the treatment of moderate to severe chronic ulcerative colitis. 【Methods】 Meta-analysis was conducted on prospective clinical trials on moderate to severe chronic ulcerative colitis with adjuvant antimicrobial therapy. 【Results】 The effective rate of antibacterial adjuvant therapy was 9% -28% higher than that of placebo, with an average of 18% higher than that of placebo. There was significant difference in efficiency (P <0.01 0). 【Conclusions】 Antimicrobials adjuvant therapy in the active phase of severe chronic ulcerative colitis has clinical value.