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以前曾有报道,胞壁酰二肽及其合成衍生物(MDP)能刺激正常动物,提高其对细菌感染的抵抗力。然而在多数情况下,需要进行治疗的患者总有某些免疫损伤或防御机能下降。因此,作者研究了合成的胞壁酰二肽衍生物6-0-硬脂酰-N 乙酰-L-丙氨酰-D-异谷氨酰胺[L18-DMP(Ala)]对于经X射线照射或环磷酰胺处理后的小鼠抗感染力的刺激作用。小鼠以10或20只为一组。感染前两天经X线照射,或腹腔注射100或200mg/kg环磷酰胺以破坏其保护力。感染前24小时每只小鼠注射100μg佐剂L18-MDP(Ala)。攻击菌为大肠埃希菌LT 0198及白色念珠菌。佐剂刺激抵抗力的效果以小鼠存活百分率表示。
It has previously been reported that muramyl dipeptide and its synthetic derivatives (MDP) can stimulate normal animals and increase their resistance to bacterial infection. However, in most cases, the patient in need of treatment always has some compromised immune function or reduced defensive function. Therefore, the authors studied the effect of the synthetic muramyl dipeptide derivative 6-0-stearoyl-N-acetyl-L-alanyl-D-isoglutamine [L18-DMP (Ala) Or cyclophosphamide-treated mice for anti-infective stimulation. The mice are grouped in 10 or 20 mice. Two days prior to infection by X-ray irradiation, or intraperitoneal injection of cyclophosphamide 100 or 200mg / kg to destroy its protective power. Twenty-four hours before infection, each mouse was injected with 100 μg of adjuvant L18-MDP (Ala). Attack bacteria Escherichia coli LT 0198 and Candida albicans. The effect of an adjuvant to stimulate resistance is expressed as a percentage of mouse survival.