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糖尿病肾病目前尚无有效的治疗手段,而早期诊断则有助于该病的控制。目前,国内对糖尿病肾病的早期诊断主要依赖于尿白蛋白(Ab)的检测,而文献报道测定尿转铁蛋白(Tf)能更早提示糖尿病肾病。我们检测了50例非胰岛素依赖型糖尿病病人的尿Tf及尿Tf与血肌酐的比值,结果均明显高于正常对照组。我们还对50例病人同时测了尿Ab、β_2-MG、IgG、THP及Ab与血肌酐的比值并作了比较。本文提示,尿Tf是糖尿病性肾病的早期诊断指标之一,若同时测定Tf/Cr的比值,则诊断的敏感性可进一步提高。
Diabetic nephropathy is currently no effective treatment, and early diagnosis is conducive to the control of the disease. At present, the early diagnosis of diabetic nephropathy in China mainly depends on the detection of urinary albumin (Ab), while the measurement of urinary transferrin (Tf) in the literature can prompt diabetic nephropathy earlier. We examined 50 patients with non-insulin-dependent diabetes urinary Tf and urinary Tf and serum creatinine ratio, the results were significantly higher than the normal control group. We also measured the ratio of urinary Ab, β_2-MG, IgG, THP, and Ab to serum creatinine in 50 patients and compared them. This article suggests that urinary Tf is one of the early diagnostic indicators of diabetic nephropathy, if the determination of Tf / Cr ratio, then the diagnostic sensitivity can be further increased.