5-溴乙酰水杨酰胺(1)为一重要中间体。其传统合成路线为溴乙酸与亚硫酰氯反应制得溴乙酰氯(收率52％),再与水杨酰胺反应制得,我们按文献试验收率为42％,后参阅有关文献采用新的合成路线,即以水杨酰胺与乙酰氯反应得5-乙酰水杨酰胺(收率90％),再与溴反应制得1(收率85％)。各步操作简单,反应条件温和,且三废污染问题较少。 Bromoacetyl salicylamide (1) is an important intermediate. Its traditional synthetic route bromoacetic acid and thionyl chloride reaction of bromoacetyl chloride (yield 52%), and then with salicylamide obtained by our experiment, according to the literature experimental yield of 42%, after the reference to the literature using a new The synthetic route, that salicylamide with acetyl chloride 5-acetylsalicylamide (yield 90%), and then bromine reaction 1 (yield 85%). Each step is simple, mild reaction conditions, and less waste pollution problems.