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目的检测RUNX3在人胃腺癌组织、正常组织及不典型增生组织中的表达情况,分析它们的表达与胃癌临床病理参数的关系,探讨在胃癌发生发展中的作用。方法应用免疫组织化学染色S-P法检测82例人胃癌标本、30例癌旁正常组织、30例轻度不典型增生组织、30例重度不典型增生组织中RUNX3的表达,结合临床和病理资料进行分析。结果RUNX3在胃癌中的阳性表达率为64.63%,明显低于在癌旁正常组织(90%)及轻度不典型增生组织(86.67%)中的表达率,差别具有统计学意义(P<0.05),在重度不典型增生组织中的表达率为73.33%,差别不具有统计学意义(P>0.05)。患者的腹痛缓解天数及住院时间治疗组明显小于对照组外(P<0.05)。RUNX3表达与胃癌的Lauren分型、淋巴结转移呈负相关,而与性别、年龄、临床分期、病理分级、浸润深度无关(P>0.05)。结论RUNX3蛋白对人胃癌的产生和发展起重要作用。
Objective To detect the expression of RUNX3 in human gastric adenocarcinoma, normal tissue and atypical hyperplasia tissues, and to analyze their relationship with the clinicopathological parameters of gastric cancer and to explore the role of RUNX3 in the development and progression of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of RUNX3 in 82 specimens of human gastric cancer, 30 specimens of adjacent normal tissues, 30 specimens of mild atypical hyperplasia and 30 specimens of severe atypical hyperplasia, and to analyze the clinical and pathological data . Results The positive rate of RUNX3 in gastric cancer was 64.63%, which was significantly lower than that in normal adjacent tissue (90%) and mild dysplasia (86.67%), the difference was statistically significant (P <0.05 ) In severe dysplasia tissues was 73.33%, the difference was not statistically significant (P> 0.05). The number of patients with abdominal pain relief and hospitalization time was significantly less than the control group (P <0.05). RUNX3 expression was negatively correlated with Lauren classification and lymph node metastasis of gastric cancer, but not with gender, age, clinical stage, histological grade and depth of invasion (P> 0.05). Conclusion RUNX3 protein plays an important role in the generation and development of human gastric cancer.