【摘 要】
：
Circular RNAs (circRNAs) play either oncogenic or tumor suppressive roles in gastric cancer (GC).A previous study demonstrated that circ_002059,a typical circRN
【机 构】
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Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 2300
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Circular RNAs (circRNAs) play either oncogenic or tumor suppressive roles in gastric cancer (GC).A previous study demonstrated that circ_002059,a typical circRNA,was downregulated in GC tissues.However,the role and mechanism of circ_002059 in GC development are still unknown.In this study,the levels of circ_002059,miR-182,and metastasis suppressor-1 (MTSS1) were examined by real-time quantitative polymerase chain reaction and western blot analysis.Cell proliferation and migration were evaluated by MTT assay and Transwell migration assay,respectively.The interactions between miR-182 and circ_002059 or MTSS1 were analyzed by dual-luciferase reporter assay.A GC xenograft model was established to validate the role of circ_002059 in GC progression in vivo.Overexpression of circ_002059 significantly inhibited,whereas knockdown of circ_002059 notably facilitated,cell proliferation and migration in GC cells.MTSS1 was found to be a direct target of miR-182 and circ_002059 upregulated MTSS1 expression by competitively sponging miR-182.Transfection with miR-182 mimic and MTSS1 silencing abated the inhibitory effect of circ_002059 on GC progression.Circ_002059 inhibited GC cell xenograft tumor growth by regulating miR-182 and MTSS1 expression.Collectively,Circ_002059 inhibited GC cell proliferation and migration in vitro and xenograft tumor growth in mice,by regulating the miR-182/MTSS1 axis.
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