论文部分内容阅读
大白鼠６０只按血胆固醇（ＴＣ）水平随机排序，分成基础饲料、脂肪乳、脂肪乳＋高（２．０ｍｌ／ｋｇ）、中（１．０ｍｌ／ｋｇ）、低（０．５ｍｌ／ｋｇ）剂量淡水鱼油组、脂肪乳＋氯贝丁酯（２００ｍｇ／ｋｇ）组．家兔２０只分成脂肪乳、脂肪乳＋高、低剂量鱼油组和＋氯贝丁酯组．测定给予试验物品前及其后１０ｄ和４周的血ＴＣ、甘油三酯（ＴＧ）、低密度脂蛋白－胆固醇（ＬＤＬ－Ｃ）、高密度脂蛋白－固醇（ＨＤＬ－Ｃ）等项指标．结果显示，淡水鱼油对脂肪乳所致大鼠高血脂的ＴＣ有明显降低，并剂量依赖性地降低ＴＧ、ＬＤＬ－Ｃ；对实验性高血脂家兔的ＴＣ、ＴＧ和ＬＤＬ－Ｃ均明显降低，其高剂量组降低更明显（Ｐ＜０．０１）．各鱼油组与氯贝丁酯组比较，其降低ＴＣ、ＬＤＬ－Ｃ的效果无明显差异（Ｐ＞０．０５）．
Sixty rats were randomly divided according to the level of blood cholesterol (TC) into basic diet, fat emulsion, fat emulsion + high (2.0ml / kg) Dose freshwater fish oil group, fat emulsion + clofibrate (200mg / kg) group. 20 rabbits were divided into fat emulsion, fat emulsion + high and low dose fish oil group and + clofibrate group. Blood TC, triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-sterol (HDL-C) were measured before and after the administration of the test article . The results showed that freshwater fish oil significantly decreased the TC of lipid-induced hyperlipidemia in rats and reduced TG and LDL-C in a dose-dependent manner, and significantly decreased TC, TG and LDL-C in experimental hyperlipidemic rabbits , Its high-dose group decreased more significantly (P <0.01). The fish oil group and the clofibrate group, the effect of reducing TC, LDL-C was no significant difference (P> 0.05).