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目的 探讨在SD大鼠过敏性气道炎症情况下气道阻力及气道对乙酰胆碱的反应性变化情况。方法 作者用卵清蛋白免疫和激发SD大鼠。以气道阻力较基线值升高 2 0 0 %时所需乙酰胆碱的负对数浓度( LogPC2 0 0 )为标准检测气道反应性。结果 哮喘组基础气道阻力值较对照组明显升高 (从 2 2 82± 0 12 8到 3 193± 0 2 39;P <0 0 1)。反复过敏原激发后气道对乙酰胆碱的反应性明显降低 ( LogPC2 0 0 从 4 0 0 6± 0 5 5 4到 2 0 5 9± 0 2 6 2 ;P <0 0 1)。支气管肺泡灌洗液和肺组织病理切片均证实过敏性气道炎症存在。结论 本研究证实反复过敏原激发后支气管收缩反应和气道高反应性不存在相关性 ,同时提示反复过敏原激发后虽然出现过敏性气道炎症 ,但气道反应性降低伴持续支气管收缩反应。
Objective To investigate the changes of airway resistance and airway responsiveness to acetylcholine in allergic airway inflammation in SD rats. Methods The authors immunized and challenged SD rats with ovalbumin. Airway responsiveness was measured as the negative logarithmic concentration of acetylcholine (LogPC2 0 0) required to increase airway resistance by 200% from baseline. Results The baseline airway resistance of asthma group was significantly higher than that of the control group (from 2282 ± 0128 to 3393 ± 0 2 39; P <0.01). After repeated allergen challenge the airway responsiveness to acetylcholine was significantly reduced (LogPC2 0 0 from 4 0 6 ± 0 5 5 4 to 2 0 5 9 ± 0 2 6 2; P 0 01). Bronchoalveolar lavage fluid and lung biopsy confirmed the presence of allergic airway inflammation. Conclusions This study demonstrates that there is no correlation between bronchoconstriction and airway hyperresponsiveness after repeated allergen challenge, and suggests that although allergic airway inflammation occurs after repeated allergen challenge, airway responsiveness decreases with persistent bronchoconstriction.