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目的建立花生四烯(arachidonic acid,AA)人体皮肤炎症模型。方法在12名健康志愿者前臂屈侧做0.16%AA、0.8%AA、4%AA、20%AA、100%AA浓度的点刺试验,分别记录其30min红斑面积、风团面积。并在其服用咪唑斯汀后1h进行AA点刺试验,记录点刺试验30min后的红斑面积和风团面积。结果炎症模型中以20%AA产生的红斑、风团表现较为稳定,且服用咪唑斯汀前与服用后1h红斑面积及风团面积变化显著(P<0.01)。结论通过点刺试验可建立稳定的AA人体皮肤炎症模型。
Objective To establish a human skin inflammation model of arachidonic acid (AA). Methods Twelve prickles of healthy volunteers were pricked with 0.16% AA, 0.8% AA, 4% AA, 20% AA and 100% AA for 30 min. And 1h after taking mizolastine AA prick test, recording prick test after 30min erythema area and wind group area. Results The erythema and gustomeres produced by 20% AA in the model of inflammation were stable, and the area of erythema and the area of gusts 1 h before and after administration of mizolastine significantly changed (P <0.01). Conclusion Stable AA human skin inflammation model can be established by prick test.