论文部分内容阅读
目的:分析中药微调五号方联合生物反应调节剂重组人白介素-2(IL-2)、重组人干扰素α2b(IFN-α2b)对肾癌患者肿瘤标志物及生活质量的影响。方法:将50例肾癌患者用双盲法分为对照组(IFN-α2b、IL-2皮下注射)、观察组(加用中药微调五号)。统计客观疗效中缓解率、治疗前后肿瘤标志物水平、T细胞亚群主要指标变化,记录QLQ-C30生命质量、生活质量卡氏评分(KPS)分值,记录Ⅲ度、Ⅵ度不良反应发生率。结果:治疗后,观察组缓解率(24.00%)与对照组无显著差异,P>0.05;观察组NSE低于对照组;观察组CD_4~+升高,CD_8~+下降,CD_4~+/CD_8~+升高,均优于对照组;观察组除认知功能分值外QLQ-C30其它指标分值均高于对照组;观察组卡氏评分高于对照组;观察组Ⅲ度、Ⅵ度不良反应发生率(4.00%)低于对照组。均P<0.05。结论:中药微调五号联合生物反应调节剂能显著抑制部分肿瘤标志物,提高患者免疫力,改善生命质量和生活质量,减少严重不良反应,值得推广。
OBJECTIVE: To analyze the effects of traditional Chinese medicine (TCM) fine-tuning the combination of recombinant human interleukin-2 (IL-2) and interferon-α 2b (IFN-α2b) on tumor markers and quality of life in patients with renal cell carcinoma. Methods: Fifty patients with renal cell carcinoma were divided into control group (IFN-α2b and IL-2 subcutaneously) by double-blind method and observation group (with Chinese medicine trimming fifth). Statistical objective response rate of remission, the level of tumor markers before and after treatment, changes of T cell sub-index, QLQ-C30 quality of life and KPS scores were recorded, and the incidence of grade Ⅲ and Ⅳ adverse reactions was recorded . Results: After treatment, the remission rate in the observation group (24.00%) was not significantly different from that in the control group (P> 0.05). The NSE in the observation group was lower than that in the control group. The CD_4 ~ +, CD_8 ~ +, CD_4 ~ + / ~ + Increased in the observation group than in the control group. The scores of other indexes of QLQ-C30 in the observation group were higher than those in the control group except for the cognitive function score; the observation group’s Karnofsky score was higher than the control group; The incidence of adverse reactions (4.00%) was lower than that of the control group. All P <0.05. Conclusion: Chinese medicine fine adjustment joint No. 5 combined with biological response modifier can significantly inhibit some tumor markers, improve patient immunity, improve quality of life and quality of life, reduce serious adverse reactions, it is worth promoting.