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目的 Ｃｙｃｌｉｎ Ｅ 蛋白在细胞周期的Ｇ１ 晚期起作用，加速Ｇ１Ｓ期转化，与人类肿瘤有关． 本研究探讨ｃｙｃｌｉｎ Ｅ 蛋白在胃癌的意义．方法 用敏感而特异的免疫组化ＳＰ 法测定胃癌石蜡切片中ｃｙｃｌｉｎ Ｅ蛋白的异常表达．结果 Ｃｙｃｌｉｎ Ｅ 在胃癌中表达６２ ％ （ｎ ＝ ６０ ，Ｍ＝ ４３ ，Ｆ＝ １７ ，３２岁～７３ 岁） ，与癌旁组织２６ ％ 相比有显著差异（ Ｐ＜ ０－０５） ．Ｃｙｃｌｉｎ Ｅ表达与组织病理分化程度呈负相关． 分化差的胃癌组织ｃｙｃｌｉｎ Ｅ蛋白表达越强，ｃｙｃｌｉｎ Ｅ与肿瘤侵袭、淋巴结转移、远处转移无明显关系．结论 Ｃｙｃｌｉｎ Ｅ 蛋白与胃癌发生有关，与胃癌进展无关．ＣｙｃｌｉｎＥ 蛋白可做为胃癌的一个潜在的诊断和判断预后的指标．
Objective The cyclin E protein plays a role in the late G1 phase of the cell cycle and accelerates the G1-S phase transformation, which is related to human tumors. This study investigated the significance of cyclin E protein in gastric cancer. Methods Sensitive and specific immunohistochemical SP method was used to determine the abnormal expression of cyclin E protein in paraffin sections of gastric cancer. Results The expression of Cyclin E in gastric carcinoma was 62% (n = 60, M = 43, F = 17, 32-73), and it was significantly different from that in paratumor tissue (P < 0-05). The expression of Cyclin E was negatively correlated with histopathological differentiation. The poorer differentiation of gastric cancer tissue cyclin E protein expression is stronger, cyclin E and tumor invasion, lymph node metastasis, distant metastasis no significant relationship. Conclusion Cyclin E protein is related to the occurrence of gastric cancer and has nothing to do with the progression of gastric cancer. CyclinE protein can be used as a potential diagnostic and prognostic indicator of gastric cancer.