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目的:研究盐酸异丙嗪在聚中性红修饰碳糊电极(PNR/CPE)上的电化学行为,建立一种修饰电极测定盐酸异丙嗪含量的新方法。方法:采用循环伏安法(CV)研究碳糊电极(CPE)上电聚合制备聚中性红膜的最佳聚合条件及盐酸异丙嗪在该修饰电极上的电化学行为,以方波伏安法(SWV)对盐酸异丙嗪进行含量分析。结果:中性红在碳糊电极上聚合效果很好,对盐酸异丙嗪有着良好的电催化氧化作用,与CPE相比,盐酸异丙嗪在PNR/CPE上的氧化峰电流增加约5倍,其峰电流与浓度在1.0×10-6～1.0×10-3mol.L-1范围内呈现良好的线性关系,检出限为2.0×10-7mol.L-1。结论:该法灵敏度高,可用于盐酸异丙嗪片的测定。
Objective: To study the electrochemical behavior of promethazine hydrochloride on poly (neutral red) modified carbon paste electrode (PNR / CPE) and to establish a new method for the determination of promethazine hydrochloride by modified electrodes. Methods: Cyclic voltammetry (CV) was used to study the optimum polymerization conditions for the preparation of poly (neuramolecular) red film by electropolymerization of CPE and the electrochemical behavior of promethazine hydrochloride on the modified electrode. Anfu (SWV) content of promethazine hydrochloride. Results: Neutral red polymerized well at the carbon paste electrode and good electrocatalytic oxidation of promethazine hydrochloride. Compared with CPE, the oxidation peak current of promethazine hydrochloride on PNR / CPE increased about 5 times , The peak current and concentration in the range of 1.0 × 10-6 ~ 1.0 × 10-3mol.L-1 showed a good linear relationship with a detection limit of 2.0 × 10-7mol.L-1. Conclusion: The method is sensitive and can be used for the determination of promethazine hydrochloride tablets.