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本文旨在研究左旋咪唑(Levamisole)对食管癌的预防作用。食管癌前病变是食管癌发病过程中的必经阶段,防治食管癌前病变是预防食管癌的重要措施。Wistar大鼠82只,用甲基戊基亚硝胺(N—methyi—N—amylnitrosamine,简称MANA)诱发食管上皮增生,经105天实验显示左旋咪唑(每天10mg/kg,6次/周)具有与太洛龙相似的抑制食管癌前病变作用,并降低血清中MANA的含量。但是,左旋咪唑使大鼠体重增加变快,而太洛龙则使之变慢。结果表明左旋咪唑为优。
This article aims to study the preventive effect of levamisole on esophageal cancer. Esophageal precancerous lesions is an essential stage in the pathogenesis of esophageal cancer, prevention and treatment of esophageal precancerous lesions is an important measure to prevent esophageal cancer. Eighty Wistar rats were induced to develop esophageal epithelial hyperplasia by N-methyi-N-amylnitrosamine (MANA). After 105 days, levamisole (10 mg / kg daily, 6 times a week) It is similar to deloxacin in inhibiting esophageal precancerous lesion and reducing the content of MANA in serum. However, levamisole allowed rats to gain weight faster, while tylosin slowed it. The results show that levamisole is excellent.