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目的探析两种非吡嗪酰胺化疗方案治疗肺结核合并糖尿病高尿酸血症效果。方法将160例肺结核合并糖尿病高尿酸血症患者随机分为两组,给予不同的非吡嗪酰胺化疗方案治疗:Ⅰ组采用2AHRE/7HR化疗方案,即阿米卡星+异烟肼+利福平+乙胺丁醇;Ⅱ组采用2LHRE/7HR化疗方案,即左氧氟沙星+异烟肼+利福平+乙胺丁醇。结果Ⅰ组总有效率为71.2%,不良反应发生率为18.8%,Ⅱ组分别为86.2%、3.8%,组间比较差异均具有统计学意义(P<0.05)。治疗前,两组血清CD3、CD4、CD8、CD4/CD8水平比较无显著差异(P>0.05);治疗后,两组CD3、CD4、CD8、CD4/CD8明显升高,Ⅱ组CD3、CD4、CD8、CD4/CD8水平明显高于Ⅰ组(P<0.05)。结论对于肺结核合并糖尿病高尿酸血症患者,采用不含吡嗪酰胺的2LHRE/7HR方案能够提高免疫功能,疗效确切、安全性高。
Objective To investigate the effect of two non-pyrazinamide chemotherapy regimens in treating tuberculosis with hyperuricemia. Methods A total of 160 patients with pulmonary tuberculosis complicated with hyperuricemia were randomly divided into two groups and given different non-pyrazinamide chemotherapy regimens: Group Ⅰ was treated with 2AHRE / 7HR chemotherapy regimen, namely amikacin + isoniazid + Flat + ethambutol; Ⅱ group using 2LHRE / 7HR chemotherapy regimen, that is levofloxacin + isoniazid + rifampin + ethambutol. Results The total effective rate in group Ⅰ was 71.2%, the incidence of adverse reactions was 18.8% in group Ⅱ, and 86.2% and 3.8% in group Ⅱ, respectively. There was significant difference between two groups (P <0.05). Before treatment, the levels of CD3, CD4, CD8 and CD4 / CD8 in two groups had no significant difference (P> 0.05). After treatment, the levels of CD3, CD4, CD8 and CD4 / CD8, CD4 / CD8 levels were significantly higher than the group Ⅰ (P <0.05). Conclusion For patients with pulmonary tuberculosis complicated with hyperuricemia of diabetes, the 2LHRE / 7HR program without pyrazinamide can improve the immune function, which has the exact effect and high safety.