目的 探讨不同年龄精神分裂症患者间是否存在父母育龄及胎次效应的差异.方法 将380 例精神分裂症患者分为早发组( 发病年龄＜ 25 岁,200 例) ,成年发病组( 发病年龄≥25 岁,180例) ,对两组有关资料行单因素分析,并采用 HALDANE 和 SMITH 法进行父母育龄和胎次效应的估算比较.结果 与成年发病组比较,早发组精神疾病家族史较高(31?0 ％ ;χ2 ＝ 4?78 , P＜ 0?05) ,一级亲属精神分裂症的发病风险率亦较高(7?3 ％ ;χ2 ＝ 4?31 , P＜ 0?05) ;但成年发病组对本病的发生具有父母育龄及胎次效应.结论 早发组与成年发病组的父母育龄及胎次效应不同,两组存在着遗传异质性.“,”Objective To explore the possible difference in the effects of parental age(parental fertility age) and birth order between the early onset and late onset schizophrenia Methods 380 subjects who met the Chinese Classification and Diagnostic Criteria for Mental Disorders, the Second Revised Edition (CCMD 2 R) and The 4th Edition of Diagnostic and Statistical Manual of Mental Disorder (DSM Ⅳ) criteria for schizophrenia were divided into the early onset (200 cases) and late onset (180 cases) subgroups according to onset age of 25 years The data was examined with the single factor analysis, and the effects of parental bearing age and birth order were estimated by the method of Haldane and Smith Results The higher family history and the higher onset risk in the first degree relatives were noted in the early onset group than in the late onset group But the significant effects of parental bearing age and birth order were detected only in the late onset patients Conclusions It is suggested that a genetic heterogeneity may exist in early onset and late onset schizophrenic patients