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目的探讨肺表面活性物质(PS)在县区级医院治疗新生儿呼吸窘迫综合征(NRDS)的应用。方法选择2010年9月至2012年3月我院儿童急救中心新生儿重症监护病房收住入院的NRDS患儿46例,使用PS治疗者为观察组,因经济原因不能使用PS者为对照组,每组各23例。比较分析两组患儿治疗前及治疗后6 h的血气分析、机械通气时间、氧疗时间、住院时间、并发症及转归情况。结果观察组治疗后PaO2、pH值比对照组升高,PCO2比对照组降低,差异有统计学意义(P<0.05);观察组患儿的机械通气时间、氧疗时间、住院时间及病死率均低于对照组,差异有统计学意义(P<0.05)。结论应用PS治疗新生儿呼吸窘迫综合征可以提高县区级医院NRDS的救治水平,降低本地区新生儿死亡率,值得推广应用。
Objective To investigate the application of pulmonary surfactant (PS) in the treatment of neonatal respiratory distress syndrome (NRDS) in county-level hospitals. Methods From September 2010 to March 2012, 46 children with NRDS admitted to the neonatal intensive care unit of the Children’s Emergency Center in our hospital were treated with PS as the observation group. For reasons of economy, PS was used as the control group, Each group of 23 cases. Blood gas analysis, mechanical ventilation time, oxygen therapy time, hospitalization time, complication and outcome were compared before and 6 h after treatment in both groups. Results PaO2 and pH values in the observation group were higher than those in the control group and PCO2 was lower than that in the control group (P <0.05). The mechanical ventilation time, oxygen therapy time, hospital stay and mortality in the observation group Were lower than the control group, the difference was statistically significant (P <0.05). Conclusion PS treatment of neonatal respiratory distress syndrome can improve the treatment of NRDS in county-level hospitals and reduce the neonatal mortality in this area, which is worth popularizing and applying.