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Objective:This paper aims to explore the key targets and mechanism of action of Shaoyao Gancao Decoction in the treatment of cancer pain.Methods:TCMSP database was adopted to screen the active components and potential targets of Shaoyao Gancao Decoction. Genecards and OMIM databases were used to collect disease targets for cancer pain. Cytoscape software was used to construct the drug-component-target-disease network diagram. STRING database was used to draw PPI network. Finally, gene ontology (GO) enrichment analysis and KEGG pathway enrichment analysis were performed on key targets.Results:There were 98 potential targets for the treatment of cancer pain in Shaoyao Gancao Decoction. The protein interaction network suggested that IL-6, VEGFA, CASP3, EGFR and MAPK8 may be the core targets for the treatment of cancer pain in Shaoyao Gancao Decoction. GO enrichment analysis showed 127 cellular biological processes, and KEGG pathway enrichment analysis showed 116 related signaling pathways, including MPAK, AGE-RAGE, TNF, ErbB and so on.Conclusions: The treatment of cancer pain by Shaoyao Gancao Decoction may be multi-target, multi-channel and multi-level. This consequence may provide ideas and basis for further research.