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Aim:In order to elucidate the molecular mechanism underlying the cardioprotectionafforded by schisandrin B (Sch B),the effect of Sch B treatment on the sensitivityof mitochondria to Ca~(2+)-stimulated permeability transition (PT) was investigatedin rat hearts under normal and ischemia-reperfusion (I-R) conditions.Results:Myocardial I-R injury caused an increase in the sensitivity of mitochondria toCa~(2+)-stimulated PT in vitro.The enhanced sensitivity to mitochondrial PT wasassociated with increases in mitochondrial Ca~(2+) content as well as the extent ofreactive oxidant species production in vitro and cytochrome c release in vivo.The cardioprotection afforded by Sch B pretreatment against I-R-induced injurywas paralleled by the decrease in the sensitivity of myocardial mitochondria toCa~(2+)-stimulated PT,particularly under I-R conditions.Conclusion:The resultssuggest that Sch B treatment increases the resistance of myocardial mitochondriato Ca~(2+)-stimulated PT and protects against I-R-induced tissue injury.
Aim: In order to elucidate the molecular mechanism underlying the cardioprotectionafforded by schisandrin B (Sch B), the effect of Sch B treatment on the sensitivity of mitochondria to Ca 2+ -stimulated permeability transition (PT) was investigated in rat hearts under normal And ischemia-reperfusion (IR) conditions.Results: Myocardial IR injury caused by an increase in the sensitivity of mitochondria toCa~(2+)-stimulated PT in vitro.The enhanced sensitivity to mitochondrial PT was associated with increases in mitochondrial Ca~(2+) ) content as well as the extent ofreactive oxidant species production in vitro and cytochrome c release in vivo.The cardioprotection afforded by Sch B pretreatment against IR-induced injurywas paralleled by the decrease in the sensitivity of myocardial mitochondria toCa~(2+)-stimulated PT, specifically under IR conditions.Conclusion:The resultssuggest that Sch B treatment increases the resistance of myocardial mitochondriato Ca~(2+)-stimulated PT and protects agains t I-R-induced tissue injury.