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目的:探讨黄精多糖(polygona-polysaccharose,PP)对APP转基因小鼠海马CA1区突触结构的影响及其可能机制。方法:26只APP转基因小鼠,随机分为空白对照组(n=8)、低剂量黄精多糖治疗组(n=9)和高剂量黄精多糖治疗组(n=9)。采用不同浓度黄精多糖溶液对治疗组APP转基因小鼠连续ig45d后,取海马CA1区组织在透视电镜下观察,对其突触的数量、面积、变性程度及其含有突触小泡数量进行体视学分析。结果:黄精多糖治疗组突触数量增多(P<0.01);突触截面积减小且变性程度减轻(P<0.01);突触中突触小泡数量增多(P<0.01);改善程度具有一定量效关系。结论:黄精多糖能保护APP转基因小鼠海马CA1区突触结构。
Objective: To investigate the effect of polygona-polysaccharose (PP) on synaptic structure of hippocampal CA1 region in APP transgenic mice and its possible mechanism. Methods: Twenty-six APP transgenic mice were randomly divided into blank control group (n = 8), low-dose polyglucose treatment group (n = 9) and high-dose Polygonatum polysaccharide treatment group (n = 9). Using different concentrations of Polygonatum polysaccharide solution in the treatment group APP transgenic mice for ig45d, after taking hippocampal CA1 area under electron microscopic observation, the number of synapses, area, degree of degeneration and the number of synaptic vesicles were stereopsis Analysis. Results: The number of synapses in Polygonatum polysaccharide treatment group increased (P <0.01), the synaptic cross-sectional area decreased and the degree of degeneration decreased (P <0.01), the number of synaptic vesicles increased (P <0.01) A certain amount of effective relationship. Conclusion: Polygonatum polysaccharide can protect hippocampal CA1 synaptic structure in APP transgenic mice.