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目的探讨内皮素（ＥＴ）在肾综合征出血热（ＨＦＲＳ）发病机理中的作用。方法对８６例ＨＦＲＳ患者和４０例对照用ＲＩＡ法测定血浆ＥＴ动态变化。结果ＨＦＲＳ患者血浆ＥＴ在发热期、低血压休克期、少尿期和多尿期均显著高于对照组（Ｐ＜０．０５），以少尿期最为显著，恢复期降至正常；同时，ＥＴ与ＨＦＲＳ患者血清ＢＵＮ、Ｃｒ均呈高度正相关，且ＥＴ水平越高，病情越重。结论ＥＴ在ＨＦＲＳ发病过程中起重要作用，动态检测ＥＴ水平对估计病情、预后、指导治疗具有重要临床意义
Objective To investigate the role of endothelin (ET) in the pathogenesis of hemorrhagic fever with renal syndrome (HFRS). Methods 86 cases of HFRS patients and 40 cases of control by RIA plasma ET dynamic changes. Results In the HFRS patients, plasma ET was significantly higher in the period of fever, hypotension, oliguria and polyuria than in the control group (P <0.05), the most significant was oliguria, and the recovery was normal. At the same time, ET and HFRS patients serum BUN, Cr were highly positive correlation, and the higher the ET level, the more serious the disease. Conclusions ET plays an important role in the pathogenesis of HFRS. The dynamic detection of ET level has important clinical significance in estimating disease, prognosis and guiding treatment