氨基甙类抗生素(Aminoglycoside Antibiotics,简作AmAn)临床应用极为普遍。但是,自1949年Can-sse首次报道AmAn对内耳感受器有损伤以来,国内外大量文献陆续报道了该类药物对内耳毒性的临床及实验研究。迄今已知全部AmAn都具有损害内耳的副作用,部分主要侵犯螺旋器,部分则主要侵犯前庭。AmAn耳毒性作用发生率较高,如庆大霉素和丁胺卡那霉素为 1～2％,卡那霉素为10 ％。虽然其耳毒性机理至今尚未彻底阐明,但近年来的研究取得不少进展。 Aminoglycoside Antibiotics (AmAn) clinical application is extremely common. However, since Can-sse first reported in 1949 that AmAn had damage to inner ear receptors, a large number of literatures at home and abroad reported on the clinical and experimental studies on the toxicity of these drugs to the inner ear. So far all known AmAn have the side effects of damaging the inner ear, some mainly infringe the helix, some of the main violations of the vestibule. AmAn ototoxic effects of higher incidence, such as gentamicin and amikacin 1 to 2%, kanamycin 10%. Although its ototoxicity mechanism has not yet been completely elucidated, but in recent years, research has made considerable progress.