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目的探讨血液灌流联合血液透析治疗急性铊中毒的疗效及安全性。方法对本院2012年9月收治的4例急性铊中毒患者,在常规治疗的基础上,采用血液透析器串联灌流器进行血液净化治疗,比较治疗前后患者尿铊水平及临床症状。结果 4例患者治疗前尿铊水平为481.4~2 225.0(中位数为1 366.5)μg/L,进行血液灌流联合血液透析治疗3 d后,尿铊水平下降为24.6~154.7(中位数为57.8)μg/L,消化系统和神经系统的临床症状均有好转。结论血液灌流联合血液透析对急性铊中毒的治疗效果显著,无明显不良反应,值得临床推广使用。
Objective To investigate the efficacy and safety of hemoperfusion combined with hemodialysis in the treatment of acute thallium poisoning. Methods Four patients with acute thallium poisoning admitted to our hospital in September 2012 were treated with hemodialyzer serial flow perfusion device on the basis of routine treatment. Blood urea chloride level and clinical symptoms were compared before and after treatment. Results Before treatment, the level of urinary thallium was 481.4-2 225.0 (median 1 366.5) μg / L in 4 patients. After 3 days of hemoperfusion and hemodialysis, the level of urinary thallium dropped to 24.6-154.7 (median: 57.8) μg / L, the clinical symptoms of the digestive system and nervous system have improved. Conclusion Hemoperfusion combined hemodialysis treatment of acute thallium poisoning significant effect, no significant adverse reactions, it is worth promoting the use of the clinic.