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目前认为幽门螺杆菌(HP)与十二指肠溃疡复发有密切关系。在治疗十二指肠溃疡的同时采用彻底杀灭HP的疗法,可大大降低溃疡复发率。最有效的抗HP疗法通常由三种药物组成,这些药日服3～4次,连服2～6周。本文作者作随机对照试验,研究能否在一周内彻底杀死 HP。病人与方法作者对用内镜确诊为十二指肠溃疡的病人194例作胃窦活检,选出尿素酶测定阳性的病人155例。再随机分为两组,其中①组77例,单服奥美拉唑4周;②组78例,在第1周服用奥美拉唑,同时每日4次加服胶体次柠檬酸铋120mg、四环素500mg 及灭滴灵400mg,以后3周单服奥美拉唑。停药4周后再做胃镜观察溃疡情况,并做胃窦部活组织显微镜观察、细菌培养及尿素酶测定。结果最初检查的194例中,只有消化不
It is currently believed that Helicobacter pylori (HP) and duodenal ulcer recurrence are closely related. In the treatment of duodenal ulcer with thorough treatment of HP therapy can greatly reduce the ulcer recurrence rate. The most effective anti-HP therapy is usually composed of three drugs, these drugs 3 to 4 times a day, and even for 2 to 6 weeks. The authors of this randomized controlled trial examines whether HP can be thoroughly killed within a week. Patients and Methods The authors of 194 patients with endoscopic diagnosis of duodenal ulcer for gastric antrum biopsy, selected urease test positive for 155 patients. Then randomly divided into two groups, of which ① group of 77 patients, single-dose omeprazole for 4 weeks; ② group of 78 patients taking omeprazole in the first week, plus 4 times a day plus subcutaneous bismuth subchlorate 120mg , Tetracycline 500mg and metronidazole 400mg, after 3 weeks single-dose omeprazole. After 4 weeks of discontinuation of gastroscopy to observe the ulcer, and do gastric anastomosis microscopy, bacterial culture and urease determination. The results of the initial examination of 194 cases, only digestion is not