目的研究有机氯化合物二氯二苯三氯乙烷(DDT)、六氯环乙烷(HCH)和多氯联苯(PCBs)在宁夏女性人群中的内暴露水平及与乳腺癌患病风险的关系。方法采用1∶1的病例-对照研究,收集确诊的新发乳腺癌患者和同一医院的非肿瘤患者各92名。采用问卷调查表收集病例及对照的乳腺癌相关危险信息。采用气相色谱-电子捕获(GC-ECD)方法检测血清中有机氯化合物的残留水平。运用条件Logistic回归模型分析有机氯化合物的血清水平与乳腺癌患病风险的相对危险度(OR)。结果 15种有机氯农药残留物在病例和对照血清中均有检出,其中β-HCH、δ-HCH、p,p’-DDE、PCB28及PCB52的检出率高于90%;β-HCH、p,p’-DDE和PCB52的检出水平在乳腺癌组和对照组间差异有显著性(P<0.05);控制了混杂因素后,β-HCH、p,p’-DDE和PCB52暴露与乳腺癌患病呈正相关(OR>2,P<0.05)。结论有机氯残留物(DDT、HCH和PCB)可能增加妇女患乳腺癌的风险。 Objective To study the level of exposure of DDT, HCH and PCBs in Ningxia female population and its relationship with the risk of breast cancer relationship. Methods A 1: 1 case-control study was performed, with 92 newly diagnosed breast cancer patients and 92 non-cancer patients in the same hospital. A questionnaire was used to collect case-based and control-related breast cancer-related risk information. The levels of organochlorine compounds in serum were determined by gas chromatography-electron capture (GC-ECD). The conditional logistic regression model was used to analyze the relative risk (OR) of serum levels of organochlorine compounds and the risk of breast cancer. Results 15 kinds of organochlorine pesticide residues were detected in both cases and control sera. The detection rates of β-HCH, δ-HCH, p, p’-DDE, PCB28 and PCB52 were higher than 90% The levels of p, p’-DDE and PCB52 were significantly different between breast cancer group and control group (P <0.05). After the confounding factors were controlled, β-HCH, p, p’-DDE and PCB52 And breast cancer was positively correlated (OR> 2, P <0.05). Conclusions Organochlorine residues (DDT, HCH and PCB) may increase the risk of breast cancer in women.