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甲氰咪胍(cimetine、tagamet)是一种H_2受体阻滞剂,作为治疗消化系统疾病的新药,目前已在国内广泛使用。临床用药发现当它与其它药物并用时,有的可产生协同作用,增强疗效,有的则产生不良反应。现扼要概述如下: 一、甲氰咪胍对其它药物的影响 (一)对其它药物吸收的影响甲氰咪胍可阻断组织胺H_2受体,抑制胃酸分泌,使胃和近端肠腔内的pH值升高,因而可对某些药物产生影响,特别是有些对酸不稳定的药物,或其吸收量由离子化决定时,其生物利用度可受甲氰咪胍的影响。 1.服用甲氰咪胍时,由于胃酸分泌减少,可降低铁剂的吸收量。 2.使强的松龙肠溶片的溶解发生改变,导致胃肠
Cimetidine (cimetine, tagamet) is a H 2 receptor blocker, as a new drug for the treatment of digestive diseases, has been widely used in China. Clinical medication found that when it is used in combination with other drugs, some can produce synergies, enhance the efficacy, while others have adverse reactions. Now briefly summarized as follows: First, the impact of cimetidine on other drugs (a) the impact on other drug absorption Cimetidine can block the histamine H 2 receptors, inhibit gastric acid secretion, the stomach and proximal intestine Of the pH value, which can affect some drugs, especially some of the acid-labile drugs, or its absorption by the ionization of the decision, its bioavailability by cimetidine influence. 1. taking cimetidine, due to reduced gastric acid secretion, iron absorption can be reduced. 2. So that the dissolution of prednisolone enteric-coated tablets change, leading to gastrointestinal