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目的探讨FHIT、MSH2在宫颈癌发生、发展中的作用及其相互关系。方法应用免疫组织化学SP法对35例宫颈癌、57例宫颈上皮内瘤变(CIN)和20例对照组中FHIT、MSH2的表达进行检测。结果 FHIT在正常宫颈、CIN和宫颈癌中的阳性率分别为90.0%、73.7%和22.9%,差异有显著性(P<0.01);宫颈癌中FHIT表达在汉族(42.9%)和维吾尔族(10.5%)间的差异有显著性(P<0.05)。MSH2蛋白在正常宫颈、CIN和宫颈癌的阳性率分别为65.0%、63.2%和71.4%,差异无显著性(P>0.05)。FHIT和MSH2在宫颈癌中的表达无相关性(r=0.043,P>0.05)。结论新疆地区宫颈癌的发生与FHIT表达降低或缺失有关,且维吾尔族妇女FHIT表达异常更明显;FHIT在CIN中的缺失可作为宫颈癌的筛查和早期诊断指标;CIN向宫颈癌发展过程中,MSH2表达有逐渐升高的趋势;但FHIT和MSH2在宫颈癌中的表达无相关性。
Objective To investigate the role of FHIT and MSH2 in the occurrence and development of cervical cancer and their relationship. Methods The expressions of FHIT and MSH2 in 35 cases of cervical cancer, 57 cases of cervical intraepithelial neoplasia (CIN) and 20 cases of control group were detected by immunohistochemical SP method. Results The positive rates of FHIT in normal cervix, CIN and cervical cancer were 90.0%, 73.7% and 22.9%, respectively (P <0.01). FHIT expression in cervical cancer was higher in Han (42.9%) and Uygur 10.5%) (P <0.05). The positive rates of MSH2 protein in normal cervix, CIN and cervical cancer were 65.0%, 63.2% and 71.4% respectively, with no significant difference (P> 0.05). There was no correlation between FHIT and MSH2 expression in cervical cancer (r = 0.043, P> 0.05). Conclusions The occurrence of cervical cancer in Xinjiang is related to the decrease or deletion of FHIT expression and the abnormal expression of FHIT in Uighur women. The deletion of FHIT in CIN can be used as a screening and early diagnosis indicator of cervical cancer. , MSH2 expression gradually increased trend; but FHIT and MSH2 in cervical cancer expression no correlation.