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目的 :探讨抑癌基因Smad4在胰腺癌组织中的表达及其临床意义。方法 :应用免疫组化技术 (SABC法 )检测Smad4基因表达产物在 42例胰腺癌、13例急慢性胰腺炎和 12例正常胰腺组织中的表达。结果 :Smad4在胰腺癌、急慢性胰腺炎和正常胰腺组织中阳性表达率分别为 5 2 3 8% ,84 62 %和 91 67% ,Smad4蛋白表达与胰腺癌患者性别、年龄、肿瘤发生部位、组织学分级以及临床分期均无统计学意义 (P >0 0 5 )。结论 :Smad4在胰腺癌组织中表达降低 ,对鉴别胰腺癌与胰腺炎可能具有一定的实用价值。
Objective: To investigate the expression of Smad4 in pancreatic cancer and its clinical significance. Methods: The expression of Smad4 gene in 42 cases of pancreatic cancer, 13 cases of acute and chronic pancreatitis and 12 cases of normal pancreas was detected by immunohistochemistry (SABC method). Results: The positive expression rates of Smad4 in pancreatic cancer, acute and chronic pancreatitis and normal pancreatic tissues were 52.38%, 84.62% and 91.67% respectively. The expression of Smad4 was positively correlated with the gender, age, tumor location, Histological grade and clinical stage were not statistically significant (P> 0.05). Conclusion: The decreased expression of Smad4 in pancreatic cancer may be of practical value in differential diagnosis of pancreatic cancer and pancreatitis.