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目的:评价参茸方对新药联合铂类方案对晚期非小细胞肺癌血液毒性及消化道反应的减毒作用。方法:拟进行各种化疗方案治疗的40例患者,随机分成参茸方先治疗组和参茸方后治疗组,每组各20例。参茸方先治疗组于第1周期化疗第1天开始,每天服参茸方1剂,连续10天,同时实施化疗(治疗周期);第2周期仅实施原化疗方案(对照周期)。参茸方后治疗组第1周期仅实施化疗方案(对照周期);第2周期化疗在实施原化疗方案的同时,每天服参茸方1剂,连续10天(治疗周期)。通过随机自身前后交叉对照,观察参茸方对化疗血液毒性及消化道反应的影响。结果:2组治疗周期的血液毒性(白细胞、中性粒细胞减少)及消化道反应(恶心、呕吐)均较对照周期低(P<0.05,P<0.01)。其中参茸方先治疗组治疗周期的血液毒性及消化道反应均较对照周期低(P<0.05),参茸方后治疗组两周期的比较未见显著性差异。结论:参茸方能减轻以铂类为基础的化疗方案治疗非小细胞肺癌时的血液毒性及消化道反应。早期联合应用参茸方,减毒作用更好。
OBJECTIVE: To evaluate the attenuated effect of ginseng and Chinese herb on the hematotoxicity and gastrointestinal reaction of advanced non-small cell lung cancer (NSCLC) combined with platinum-based regimen. Methods: Forty patients who were treated with various chemotherapeutic regimens were randomly divided into the ginseng and ginseng group and the ginseng group after treatment, with 20 cases in each group. Ginseng Fang Xian treatment group in the first cycle of chemotherapy started on the first day of serving a ginseng day, for 10 days, while the implementation of chemotherapy (treatment cycle); the second cycle only the implementation of the original chemotherapy regimen (control cycle). Ginseng treatment group only after the first cycle of chemotherapy regimen (control cycle); the second cycle of chemotherapy in the implementation of the original chemotherapy regimen, the daily service ginseng Fang 1, continuous 10 days (treatment cycle). By random cross-control before and after their own to observe the ginseng Fang on chemotherapy blood toxicity and gastrointestinal reactions. Results: Hemotoxicity (leukopenia, neutropenia) and digestive tract reaction (nausea and vomiting) in the two groups were lower than those in the control group (P <0.05, P <0.01). Among them, the hematotoxicity and digestive tract reaction of the treatment group of ginseng Fangxian treatment group were lower than that of the control period (P <0.05). There was no significant difference between the two groups after the treatment of ginseng group. Conclusion: Ginseng can alleviate the hematotoxicity and gastrointestinal reaction in the treatment of non-small cell lung cancer with platinum-based chemotherapy. Early joint application of ginseng, attenuated better.