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[目的]探索RSK4蛋白在结直肠癌表达情况及与其临床病理特征的关系。[方法]用免疫组化方法检测RSK4蛋白在103例经手术切除的结直肠癌组织标本和46例匹配的癌旁组织和正常结直肠组织表达情况。[结果]RSK4蛋白在结直肠癌组织中阳性表达率为15.0%(7/46),而癌旁组织中RSK4蛋白表达为41.3%(19/46),正常结直肠组织中的表达为50.0%(23/46)。结直肠癌中RSK4蛋白的表达较癌旁及正常结直肠中表达明显减少(P<0.001)。RSK4蛋白在伴淋巴结转移的结直肠癌组织中的阳性表达率为13.2%,明显低于无淋巴结转移者(37.0%,P<0.05);RSK4蛋白在中低分化(G2+G3)的结直肠癌组织中的阳性表达率为10.8%,明显低于高分化(G1)者(34.2%)(P=0.005)。在Ⅲ、Ⅳ期结直肠癌中RSK4蛋白的表达明显低于Ⅰ、Ⅱ期病例。[结论]RSK4蛋白的低表达可能与结直肠癌的发生发展和侵袭转移相关,RSK4可能是一个潜在的抑癌基因。
[Objective] To explore the relationship between the expression of RSK4 protein in colorectal cancer and its clinicopathological features. [Method] The expression of RSK4 protein in 103 resected colorectal cancer tissues and 46 matched paracancerous tissues and normal colorectal tissues were detected by immunohistochemistry. [Results] The positive rate of RSK4 protein in colorectal cancer tissues was 15.0% (7/46), while the expression of RSK4 protein in adjacent tissues was 41.3% (19/46) and that in normal colorectal tissues was 50.0% (23/46). The expression of RSK4 protein in colorectal cancer was significantly lower than that in adjacent normal and colorectal (P <0.001). The positive rate of RSK4 protein expression in colorectal cancer with lymph node metastasis was 13.2%, which was significantly lower than that in patients without lymph node metastasis (37.0%, P <0.05). RSK4 protein expression in moderately and poorly differentiated (G2 + G3) The positive expression rate in cancer tissues was 10.8%, which was significantly lower than that in patients with well-differentiated (G1) (34.2%) (P = 0.005). The expression of RSK4 protein in stage Ⅲ and Ⅳ colorectal cancer was significantly lower than that in stage Ⅰ and Ⅱ. [Conclusion] The low expression of RSK4 protein may be related to the development, invasion and metastasis of colorectal cancer. RSK4 may be a potential tumor suppressor gene.