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目的探讨急性白血病(AL)患者并发社区感染的临床特点。方法分析488例住院治疗的AL患者临床资料。结果488例AL患者共发生社区感染276例,感染部位以呼吸道、口腔、皮肤软组织和肛门为主,致病菌主要是G-菌、G+球菌和真菌,病原菌检出率低。易感因素与年龄、疾病状态、中性粒细胞(N)、血浆白蛋白和合并症有关。结论AL并发社区感染发生率高,粒细胞缺乏是AL并发社区感染的高危因素,应积极预防处理,控制易感因素是预防社区感染的有效方法,注意合理使用抗生素。
Objective To investigate the clinical characteristics of community-acquired infection in patients with acute leukemia (AL). Methods The clinical data of 488 AL patients hospitalized were analyzed. Results There were 276 community infections in 488 patients with AL. The main infection areas were respiratory tract, oral cavity, skin and soft tissue and anus. The pathogens were mainly G-, G- and cocci, and the detection rate of pathogens was low. Susceptibility factors are related to age, disease status, neutrophils (N), plasma albumin, and comorbidities. Conclusions AL complicated with high incidence of community-based infection, agranulocytosis is a risk factor for AL complicated with community-based infection should be actively prevent the treatment, control of susceptible factors is an effective way to prevent community infection, pay attention to the rational use of antibiotics.