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目的探讨单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效。方法选取福州儿童医院2015年2月—2016年3月收治的新生儿缺氧缺血性脑病患儿96例,按照随机数字表法分为对照组和观察组,各48例。两组患者均采用常规治疗方法,对照组给予胞二磷胆碱治疗,观察组给予单唾液酸四己糖神经节苷脂治疗,比较两组患儿的临床疗效、新生儿神经行为测定法(NBNA)评分以及症状改善时间。结果观察组治疗总有效率高于对照组(P<0.05)。且观察组患儿治疗后3、7、14d NBNA评分均高于对照组,意识恢复时间、吸吮能力恢复时间、肌张力恢复时间及原始反射恢复时间均短于对照组(P<0.05)。结论单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病临床疗效明显,可有效缩短症状改善时间。
Objective To investigate the clinical efficacy of monosialotetrahexosyl gangliosides in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods 96 cases of neonates with hypoxic-ischemic encephalopathy admitted from February 2015 to March 2016 in Fuzhou Children’s Hospital were divided into control group and observation group according to random number table method, 48 cases in each group. The two groups of patients were treated with conventional therapy, the control group was given citicoline treatment, the observation group was given monosialotetrahexosyl ganglioside treatment, the clinical efficacy of two groups were compared, neonatal neurobehavioral assay ( NBNA) score and symptom improvement time. Results The total effective rate of observation group was higher than that of control group (P <0.05). NBNA score of observation group was higher than that of control group on the 3rd, 7th and 14th day after treatment. The recovery time of consciousness, recovery time of sucking ability, recovery time of muscle tone and recovery time of original reflection were shorter than those in control group (P <0.05). Conclusion Monosialotetrahexosyl ganglioside has obvious curative effect on neonatal hypoxic-ischemic encephalopathy, which can shorten the time of symptom improvement.