论文部分内容阅读
F30066为治疗急性血吸虫病的一种非銻化合物。在治疗过程中有时可以产生一些副作用,,主要为消化道反应及肌肉痙攣,少数出现精神症状。据临床报导肌痙攣发生率較高,这种副作用虽不太严重,不影响治疗的继續,但給病人带来很大不适,甚至为此拒用此药。此外在晚期血吸虫病患者中,出现精神症状者較多见,为了了解其产生肌痙攣的机制,我们观察了該药对周围神經肌肉组織及中枢神經系統的作用。一、F 30066对离体神經及肌肉组織的影
F30066 is a non-antimony compound for the treatment of acute schistosomiasis. In the course of treatment can sometimes produce some side effects, mainly gastrointestinal reactions and muscle spasms, a small number of mental symptoms. According to clinical reports of high incidence of muscle spasm, this side effect is not too serious, does not affect the continuation of treatment, but to patients with great discomfort, and even refused to use this drug. In addition, patients with advanced schistosomiasis psychiatric symptoms were more common, in order to understand its mechanism of muscle spasms, we observed the drug on peripheral nerve and muscle and central nervous system effects. First, F 30066 of isolated nerve and muscle tissue shadow