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[目的]评价大黄蛰虫丸联合恩替卡韦治疗慢性乙型肝炎肝硬化的临床疗效。[方法]将64例慢性乙型肝炎肝硬化患者随机分成对照组和观察组,每组32例。对照组单用恩替卡韦片治疗,观察组予大黄蛰虫丸联合恩替卡韦片治疗,2组均连续治疗6个月。比较2组临床疗效和治疗前后肝功能(ALT、AST和TBIL)和肝纤维化(HA、PCⅢ、IV-C和LN)指标变化。[结果]治疗后,观察组疗效明显优于对照组(P<0.05),观察组血清ALT、AST、TBIL、HA、PCⅢ、IV-C和LN水平均显著低于对照组,差异均有统计学意义(P<0.01)。[结论]大黄蛰虫丸联合恩替卡韦可明显改善慢性乙型肝炎肝硬化患者肝功能和肝纤维化指标,疗效优于单用恩替卡韦治疗,值得临床推广应用。
[Objective] To evaluate the clinical efficacy of Rhubarb and Zicagus pills combined with entecavir in the treatment of chronic hepatitis B cirrhosis. [Method] 64 patients with chronic hepatitis B cirrhosis were randomly divided into control group and observation group, with 32 cases in each group. The control group was treated with entecavir alone, and the observation group was treated with rhubarb and zidovudine pills in combination with entecavir. Both groups were treated for 6 months continuously. The clinical efficacy and the changes of hepatic function (ALT, AST and TBIL) and hepatic fibrosis (HA, PCⅢ, IV-C and LN) were compared between the two groups before and after treatment. [Results] After treatment, the curative effect of the observation group was obviously better than that of the control group (P <0.05). The levels of ALT, AST, TBIL, HA, PCⅢ, IV-C and LN in the observation group were significantly lower than those in the control group Significance (P <0.01). [Conclusion] Rhubarb Zhechong Pill combined with entecavir can obviously improve liver function and liver fibrosis indexes of patients with chronic hepatitis B cirrhosis. The curative effect is better than that of entecavir alone, which is worthy of clinical application.