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选取30只SHR大鼠随机分为3组模型组,卡托普利组,清热降压胶囊组,wistar大鼠10只作为正常对照组,连续给药14 d后取海马组织,采用核磁共振(1H-NMR)代谢组学方法探讨高血压大鼠的海马组织损伤以及清热降压胶囊的保护作用。研究结果发现卡托普利组海马区代谢轮廓明显异于其余3组,另3组大鼠样本分类的趋势非常明显,提示清热降压胶囊能显著改善大鼠海马组织的代谢,鉴定4种代谢产物为二甲基甘氨酸、甘油磷酸胆碱、醛固酮和去甲肾上腺素。高血压大鼠机体代谢异常主要表现在酪氨酸代谢、血管平滑肌收缩以及醛固酮控制的钠盐再吸收失常,清热降压胶囊在有效降压的同时通过影响这些代谢产物来改善高血压的海马区损伤。
Thirty SHR rats were randomly divided into three groups: model group, Captopril group, Qingrejian Capsule group and wistar rats as normal control group. After 14 days of continuous administration, the hippocampus tissues were obtained, 1H-NMR) was used to investigate the damage of hippocampal tissue and the protective effect of Qingrejiangya capsule in hypertensive rats. The study found that the metabolic profile of captopril hippocampus significantly different from the other three groups, the other three groups of rats the trend of classification is very obvious, suggesting that heat-heat-lowering capsules can significantly improve the metabolism of rat hippocampal tissue identified four kinds of metabolism Products are dimethylglycine, glycerophosphocholine, aldosterone and norepinephrine. Hypertensive rats with metabolic abnormalities mainly in the tyrosine metabolism, vascular smooth muscle contraction and aldosterone-controlled sodium reabsorption disorders, heat-lowering antihypertensive capsules in the effective antihypertensive by affecting these metabolites to improve the hippocampus of hypertension damage.