Stauffer1961年首次报道5例肾源性肝功能异常综合征(NHDS,nephrogenic hepatic dysfunction syndrome)均为肾细胞癌病人,伴有肝肿大、肝功能异常、但没有肝脏癌肿转移,肾癌经手术切除后肝功能即恢复正常。此后的陆续报道,证实了这个观察。 Utz等在Mayo医院对1956～1968年之间的65个手术切除的肾细胞癌患者作肝功能试验,包括磺溴酞钠排泄试验、谷草转氨酶、血清胆红素、硷性磷酸酶、血清蛋白电泳、凝血酶原时间,每例都有3项或3项以上不正常。 Stauffer first report in 1961, 5 cases of nephrogenic liver dysfunction syndrome (NHDS, nephrogenic hepatic dysfunction syndrome) are patients with renal cell carcinoma, associated with hepatomegaly, liver dysfunction, but no liver cancer metastasis, renal cell carcinoma by surgery After resection, liver function returns to normal. Subsequent reports, confirmed this observation. Utz et al. Performed liver function tests in 65 patients with surgically resected RCC between May 1956 and May 1968, including the sulfosuccinate excretion test, aspartate aminotransferase, serum bilirubin, alkaline phosphatase, serum protein Electrophoresis, prothrombin time, each case has three or more than three are not normal.