引言在保护人类宿主,防止牙周组织严重破坏方面,已经充分确认了嗜中性白细胞的作用。循环性嗜中性白细胞数量的减少、或者其一种或多种功能的改变,往往导致严重、迅速、早发性牙周疾病。此种现象之最明显的例子是在局部性青少年牙周炎(localizedjuvenile Periodontitis LJP)病人所出现的牙周破坏。除了发病早和骨的严重丧失这些特征外,75%的 LJP 病人还表现有嗜中性白细胞功能异常,包括趋化性、吞噬作用和杀菌作用等方面的异常。由于牙周病是一种 INTRODUCTION The role of neutrophils has been well established in protecting human hosts from serious damage to periodontal tissues. A decrease in the number of circulating neutrophils, or a change in one or more of its functions, often results in severe, rapid, early-onset periodontal disease. The most obvious example of this phenomenon is the periodontal destruction that occurs in patients with localized juvenile periodontitis (LJP). In addition to the early onset and severe loss of these features, 75% of LJP patients also exhibit neutrophil dysfunction including chemotaxis, phagocytosis and bactericidal effects. Because of periodontal disease is a kind