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本研究将1994年全省36个项目县(区)发现登记的417例新发涂阳肺结核分为下述三组,对其完成治疗2年的复发情况进行对比观察。1.无痰组:治疗结束时无痰检结果患者,2.不合格痰组:治疗结束时痰标本不合格患者,3.对照组:治疗结束时有合格痰标本的治愈患者。结果显示:总复发率为2.2%,其中无痰组、不合格痰组及对照组的复发率分别为2.9%、0.0%及3.4%,三组间无显著差异(P>0.05)。研究结果证实:1.项目对初治涂阳肺结核所采用的化疗方案2H_3R_3Z_3S_3/4H_3R_3或2H_3R_3Z_3E_3/4H_3R_3是高效的,全程督导化疗管理是保证病人全程规则服药可靠又可行的管理模式;2.疗程结束时无痰患者和不合格痰患者与治愈患者同样获得满意的远期疗效。
In this study, 417 cases of newly diagnosed smear-positive pulmonary tuberculosis found in 36 project counties (districts) in 1994 were divided into the following three groups, and their recurrences after 2 years of treatment were compared. 1. No sputum group: no sputum examination results at the end of treatment patients, 2. unqualified sputum group: sputum samples at the end of treatment failed patients, 3. control group: at the end of treatment with qualified sputum specimens cured patients. The overall recurrence rate was 2.2%. The recurrence rates were 2.9%, 0.0% and 3.4% in the sputum-negative sputum group and the unqualified sputum group, respectively, with no significant difference among the three groups (P> 0.05). The results of the study confirmed: 1. The project is highly effective in the treatment of chemotherapy-naive pulmonary tuberculosis 2H_3R_3Z_3S_3 / 4H_3R_3 or 2H_3R_3Z_3E_3 / 4H_3R_3. The management of the whole course of the guideline chemotherapy is a reliable and feasible management mode for ensuring that the patient’s medication is prescribed regularly. 2. The treatment is completed When no sputum patients and unacceptable sputum patients and cured patients also get satisfactory long-term efficacy.