有些脓毒性休克病人有高动力综合征,其特征为心脏指数(CI)高和全身血管阻力指数(SVRI)低。这类病人有使用强升压药的指征,以对抗周围循环衰竭和恢复足够的组织灌注压。去甲肾上腺素(NE)是一种强升压药,能适度增加心肌收缩和引起外周血管收缩,但如用于血压正常和高血压病人,对肾血循环有不利影响,使肾血流量减少和肾血管阻力增加。脓毒性休克病人很容易发生急性肾衰(ARF),因此,使用NE有诱发ARF的危险。实验证明NE使老鼠发生缺血性ARF;对血压正常的 Some septic shock patients have hyperkinetic syndrome characterized by high cardiac index (CI) and low systemic vascular resistance index (SVRI). These patients have an indication of using strong antihypertensive drugs to combat peripheral circulatory failure and to restore adequate tissue perfusion pressure. Norepinephrine (NE) is a potent antihypertensive drug that moderately increases myocardial contractions and causes peripheral vasoconstriction but, as used in normotensive and hypertensive patients, has adverse effects on renal blood circulation and decreases renal blood flow and Renal vascular resistance increased. Patients with septic shock are prone to acute renal failure (ARF), therefore, the use of NE has the risk of ARF-induced. Experiments show that NE causes ischemic ARF in mice; for normotensive