隐性低血糖作为严重的低血糖发作一潜在危险因素已被广泛认识,但其发生频率及机制不清楚。作者从其定义内涵出发,回顾了其历史背景,综述了数十年来关于隐性低血糖的研究报道,提出低血糖所致中枢神经系统某种适应使得逆调激素和自主神经递质反应减弱,进而导致机体对胰岛素敏感性增加而对低血糖的感觉减弱,从而患者发生了频发的低血糖或严重的低血糖发作。 Hidden hypoglycemia as a potential risk factor for severe hypoglycemia has been widely recognized, but its frequency and mechanism of unclear. Based on the connotation of its definition, the author reviews its historical background, summarizes the research report about hidden hypoglycaemia for several decades, and suggests that certain adaptations of the central nervous system caused by hypoglycemia make the responses of retrotensive hormones and autonomic neurotransmitters weakened, Which in turn leads to an increased sensitivity of the body to insulin and a diminished feeling of hypoglycemia, resulting in frequent hypoglycemic episodes or severe hypoglycemic episodes.