非经典的人类白细胞抗原I类分子因其在母胎界面滋养细胞表面的独特表达及其在免疫系统中的重要作用而受到越来越多的关注。该文就非经典的人类白细胞抗原I类分子的结构、功能、基因多态性及其与妊娠免疫的关系,与病理性妊娠,如反复自然流产、妊娠期高血压疾病的相关性方面的最新进展作以综述。 Non-classical HLA class I molecules are receiving increasing attention due to their unique expression on the surface of trophoblastic cells at the maternal-fetal interface and their important role in the immune system. This article reviews the structure, function, gene polymorphism of non-classical human leukocyte antigen class I molecules and their relationship with pregnancy immunity, and the latest correlation with pathological pregnancy such as recurrent spontaneous abortion and pregnancy-induced hypertension The progress is summarized.