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系统性红斑狼疮 (systemic lupus erythem atosus,SL E)发病机理极为复杂。由于 HL A- 类抗原在免疫应答及调节中的重要作用 ,近年来 HL A基因多态性与疾病相关性一直是研究的热点。有研究显示 HL A- DR、DQ基因位点与 SL E的发病及某些类型自身抗体的形成密切相关 [1 ] 。我
The pathogenesis of systemic lupus erythem atosus (SL E) is extremely complicated. Due to the important role of HL A-type antigen in immune response and regulation, the association between HL A gene polymorphism and disease has been a hot spot in recent years. Studies have shown that HL-DR, DQ gene locus and the incidence of SL E and the formation of certain types of autoantibodies are closely related [1]. I