σ受体是一类非阿片受体,其在各种肿瘤如恶性黑色素瘤、神经胶质瘤、乳腺癌、前列腺癌和肺癌等中高度表达,而在正常组织中的表达高度保守。通过对其分类、功能、分布、配体及其在肿瘤核医学中的应用研究,将有助于肿瘤的早期诊断和针对肿瘤细胞的靶向治疗。 Sigma receptors are a class of non-opiate receptors that are highly expressed in a variety of tumors such as malignant melanoma, gliomas, breast, prostate and lung cancers, while the expression in normal tissues is highly conserved. Through its classification, function, distribution, ligand and its application in tumor nuclear medicine, it will be helpful for early diagnosis of tumor and targeted therapy of tumor cells.