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目的探究一氧化氮吸入治疗新生儿低氧性呼吸衰竭的临床效果。方法选取广西妇幼保健院2009年1月—2013年11月收治的92例低氧性呼吸衰竭患儿,随机分为治疗组47例和对照组45例。两组患儿均给予对症治疗,对照组患儿给予吸氧治疗,治疗组组患儿在对照组基础上联合一氧化氮吸入治疗。比较两组患儿治疗前后p H值、氧合指数(OI)、血氧分压(Pa O2)、血二氧化碳分压(Pa CO2)、动脉/肺泡氧张力(a/A Pa O2)、平均气道压(MAP),观察两组患儿机械通气时间及肺出血发生情况。结果两组患儿治疗前p H值、OI、Pa O2、Pa CO2、a/A Pa O2、MAP比较,差异无统计学意义(P>0.05)。治疗组患儿治疗后p H值、Pa O2、OI均高于对照组,Pa CO2、a/A Pa O2、MAP均低于对照组(P<0.05)。治疗组患儿机械通气时间为(108.0±30.5)h,短于对照组的(175.0±45.8)h(P<0.05);治疗组患儿肺出血发生率为2.1%(1/47),对照组为11.1%(5/45),差异无统计学意义(P>0.05)。结论一氧化氮吸入治疗新生儿低氧性呼吸衰竭的临床效果显著,可快速缓解患儿的临床症状。
Objective To investigate the clinical effect of nitric oxide inhalation on neonatal hypoxic respiratory failure. Methods Ninety-two children with hypoxic respiratory failure who were admitted to Guangxi Maternal and Child Health Hospital from January 2009 to November 2013 were randomly divided into treatment group (n = 47) and control group (n = 45). Two groups of children were given symptomatic treatment, control group of children given oxygen therapy, treatment group children in the control group based on the combination of nitric oxide inhalation therapy. The changes of p H, OI, Pa O2, Pa CO2 and a / A Pa O2 before and after treatment were compared between two groups. The average Airway pressure (MAP), the two groups of children with mechanical ventilation time and pulmonary hemorrhage occurred. Results There was no significant difference in p H value, OI, Pa O2, Pa CO2, a / A Pa O2, MAP between the two groups before treatment (P> 0.05). The p H value, Pa O2 and OI of children in the treatment group were higher than those in the control group after treatment, and the PaCO2, a / A PaO2 and MAP in the treatment group were lower than those in the control group (P <0.05). The duration of mechanical ventilation in the treatment group was (108.0 ± 30.5) h, shorter than that in the control group (175.0 ± 45.8) h (P <0.05). The incidence of pulmonary hemorrhage in the treatment group was 2.1% (1/47) Group was 11.1% (5/45), the difference was not statistically significant (P> 0.05). Conclusion The clinical effect of inhaled nitric oxide in the treatment of neonatal hypoxic respiratory failure is significant, which can quickly relieve the clinical symptoms of children.