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色素上皮衍生因子(pigment epithelium-derived factor,PEDF)是一种广泛存在于人体中的神经营养因子。最近研究表明PEDF具有抗血管生存活性,并对多种人类肿瘤表现出抗肿瘤作用。PEDF可能作为一种有效的抗肿瘤因子应用于临床。文中综述PEDF在肿瘤生长和转移中的作用,为肿瘤治疗寻找新方法。
Pigment epithelium-derived factor (PEDF) is a widespread neurotrophic factor in the human body. Recent studies have shown that PEDF has anti-angiogenic activity and exhibits anti-tumor effects on a variety of human tumors. PEDF may be used as an effective anti-tumor factor in clinical practice. This review summarizes the role of PEDF in tumor growth and metastasis and seeks new ways to treat cancer.