论文部分内容阅读
[目的]探讨瘦素在非肌层浸润性膀胱癌中的表达情况,组织并分析其与膀胱癌患者临床病理特征及预后的关系。[方法]收集112例膀胱移行细胞癌组织和20例正常膀胱组织的病理切片,采用免疫组化方法检测膀胱癌和正常膀胱组织中瘦素的表达。[结果]正常膀胱组织中瘦素的表达水平明显低于肿瘤组织(P=0.032)。在低级别、高级别膀胱癌中,瘦素的阳性表达率分别为43.8%、75.8%,差别有统计学意义(P=0.001)。本组随访6～102个月,其中67例出现复发。复发组与未复发组中瘦素的阳性表达率分别为70.1%和46.7%,差别有统计学意义(P=0.013)。但瘦素表达与患者年龄、性别、肿瘤数目、大小及分期无明显相关性(P>0.05)。[结论]瘦素表达在膀胱癌组织中明显高于正常膀胱组织,瘦素的检测有助于膀胱癌诊断及预后评估。
[Objective] To investigate the expression of leptin in non-muscle invasive bladder cancer and its relationship with the clinicopathological features and prognosis of bladder cancer. [Methods] Pathological sections of 112 cases of transitional cell carcinoma of the bladder and 20 cases of normal bladder tissue were collected. The expression of leptin in bladder cancer and normal bladder tissue was detected by immunohistochemistry. [Results] The expression of leptin in normal bladder tissue was significantly lower than that in tumor tissue (P = 0.032). In low-grade and high-grade bladder cancer, the positive rates of leptin were 43.8% and 75.8%, respectively, with statistical significance (P = 0.001). The group was followed up for 6 to 102 months, of which 67 cases of recurrence. The positive rates of leptin in relapsed and non-relapsed patients were 70.1% and 46.7%, respectively, with a significant difference (P = 0.013). But there was no significant correlation between leptin expression and age, sex, tumor number, size and stage (P> 0.05). [Conclusion] The expression of leptin in bladder cancer tissues is significantly higher than that of normal bladder tissue. The detection of leptin is helpful to the diagnosis and prognosis evaluation of bladder cancer.