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目的研究注射用鼠神经生长因子(nerve growth factor,NGF)佐治儿童化脓性脑膜炎后遗症强直-痉挛发作性癫痫的临床效果。方法选择2009年6月—2013年6月收治的1~6岁化脓性脑膜炎后遗症强直-痉挛发作性癫痫患儿90例作为研究对象,随机分为对照组和治疗组各45例。对照组患儿于入院后给予口服抗癫痫药物控制强制-痉挛发作,急性发作时刺激人中穴或者应用苯巴比妥钠静脉推注缓解急性发作,直至症状消失2年后停药。治疗组在对照组的基础上给予NGF肌内注射,1支/次,1次/d,4周为1个疗程。比较两组临床疗效及不良反应发生情况。计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗组显效率为86.7%,高于对照组的62.4%,差异有统计学意义(P<0.05)。结论 NGF佐治儿童化脓性脑膜炎后遗症强直-痉挛发作性癫痫疗效肯定,能显著提高临床治愈率。
Objective To study the clinical effect of injection of nerve growth factor (NGF) in children with purulent meningitis sequelae of tonic-seizure-induced epilepsy. Methods Ninety children with tonic seizure-induced epilepsy sequelae were collected from June 2009 to June 2013 in our hospital from June 2009 to June 2013, and randomly divided into control group and treatment group (n = 45). Children in the control group were given oral antiepileptic drugs after admission to control forced-spastic seizures, stimulating the acupoints in acute attack or intravenous bolus injection of phenobarbital to relieve the acute attack until symptoms disappeared 2 years later. The treatment group was given intramuscular injection of NGF on the basis of the control group, 1 / time, 1 / d, 4 weeks for a course of treatment. The clinical efficacy and adverse reactions of the two groups were compared. Count data using χ2 test, P <0.05 for the difference was statistically significant. Results The effective rate of treatment group was 86.7%, which was higher than that of control group (62.4%), the difference was statistically significant (P <0.05). Conclusion NGF adjuvant children with purulent meningitis sequelae of tonic - convulsive epilepsy positive effect, can significantly improve the clinical cure rate.