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目的分析新生儿败血症的高危因素、临床特点、细菌培养及药敏结果,以提高对此病的认识。方法分析30例新生儿败血症患儿的胎龄、出生体重、出生情况、临床特征、细菌培养及药敏结果。结果败血症患儿中,以早产、低出生体重、胎膜早破、羊水异常、出生窒息的多见;血培养以革兰阴性菌较多,其中又以大肠埃希菌为多见。结论新生儿败血症临床表现没有特异性,早产、低出生体重、胎膜早破、羊水异常、出生窒息是高危因素,细心观察、及时做血培养可以明确诊断。在病原体构成上,以革兰阴性菌较多(53.33%),其中又以大肠埃希菌为多见;在药物敏感方面,大肠埃希菌对含有β-内酰胺酶抑制剂的抗生素及亚胺培南、美罗培南敏感。早期积极治疗可得到满意疗效。
Objective To analyze the risk factors, clinical features, bacterial culture and drug susceptibility results of neonatal septicemia to improve their understanding of the disease. Methods The gestational age, birth weight, birth, clinical features, bacterial culture and drug sensitivity of 30 neonates with sepsis were analyzed. Results Sepsis in children with preterm birth, low birth weight, premature rupture of membranes, amniotic fluid abnormalities, birth asphyxia more common; Gram-negative bacteria in blood culture more, which is more common with Escherichia coli. Conclusions The clinical manifestations of neonatal septicemia are not specific. Preterm birth, low birth weight, premature rupture of membranes, amniotic fluid abnormality and birth asphyxia are risk factors. Careful observation and timely blood culture can confirm the diagnosis. In the pathogen composition, more gram-negative bacteria (53.33%), of which Escherichia coli is more common; in drug-sensitive areas, Escherichia coli containing β-lactamase inhibitor antibiotics and sub Amines Pemelopentan, Meropenem sensitive. Early active treatment can be satisfied with the effect.