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1 对心血管系统的药理作用1.1 对冠脉循环的作用丹参可以增加实验动物及人的冠状动脉流量。丹参酮Ⅱ_A 磺酸钠、丹参素被认为是其扩冠有效成分。langendorff 氏法离体心脏实验表明,丹参、复方丹参注射液增加豚鼠冠脉流量。异丙肾上腺素虽明显增加冠脉流量,但亦增加心率和心肌收缩幅度。对实验性急性心肌梗塞犬和猫、离体猫、猪的冠状动脉恒速灌注丹参素能明显扩张动脉、增加血流量,并能对抗吗啡、心得安的缩冠脉效应。在结扎狗的冠状动脉实验中发现丹
1 Pharmacological effects on the cardiovascular system 1.1 Effects on coronary circulation Salvia miltiorrhiza can increase coronary flow in experimental animals and humans. Tanshinone II_A sodium sulfonate and danshensu are considered to be the effective components of their crown expansion. Langendorff’s method in vitro heart experiments showed that Salvia miltiorrhiza and compound salvia miltiorrhiza injection increased coronary flow in guinea pigs. Although isoproterenol significantly increased coronary flow, it also increased heart rate and myocardial contraction. Persistent infusion of danshensu in coronary arteries of dogs and cats, isolated cats, and pigs with experimental acute myocardial infarction can significantly dilate arteries, increase blood flow, and counteract the coronary vasoconstrictor effect of morphine and propranolol. Dan found in the coronary artery experiment to ligate dogs