背景:在发展中国家,腹泻和营养不良仍是引起儿童死亡的主要原因,而营养不良会降低轮状病毒疫苗的效力的证据还是相互矛盾的。作者通过小鼠模型研究了轮状病毒疫苗接种(恒河猴轮状病毒,RRV)、轮状病毒感染(EDIM)和蛋白质能量失调(PEM),从而证明了营养不良会降低疫苗免疫原性和效力的假设。方法 :将正在哺乳期的3日龄野生型Balb/C幼鼠随机分配到控制饮食组(CD)或能导致PEM的等 Background: Diarrhea and malnutrition are still the leading causes of child mortality in developing countries, and evidence of malnutrition reducing the effectiveness of rotavirus vaccines remains contradictory. The authors studied rotavirus vaccination (Rhesus rotavirus, RRV), rotavirus infection (EDIM) and protein energy dysfunction (PEM) in a mouse model to demonstrate that malnutrition reduces the immunogenicity of the vaccine and The hypothesis of validity. Methods: 3-day-old wild-type Balb / C immature suckling mice were randomly assigned to control diet group (CD) or to lead to PEM